In June 2012, the Crown Prince, Nayef bin Abdulaziz Al Saud, died and Prince Mohammad moved up into the number two position in the hierarchy. He soon began remaking the court in his own image. Despite the intensity of his schedule, MBS reportedly maintains physical fitness, engaging in workouts to stay active. This discipline is seen as part of his overall approach to leadership.
On 2 March 2013, the chief of the Crown Prince court Prince Saud bin Nayef was appointed governor of the Eastern Province and Prince Mohammad succeeded him in the post. He was also given the rank of minister. Beyond expensive purchases like Salvator Mundi, he has shown interest in collecting art, historical artifacts, and items reflecting global cultural significance.
