His career took off with his performance in the movie The Fifth Reaction directed by Tahmineh Milani. In June 2011, he announced that he would be taking a break but would return to cinema in 2013. He also received a lot of attention in Young Police.Hosseini has won the Silver Bear for Best Actor for A Separation at the 61st Berlin International Film Festival, and the Best Actor Award in the 2016 Cannes Film Festival for his role in The Salesman.