De Gaulle married Yvonne Vendroux on 7 April 1921 in Église Notre-Dame de Calais. They had three children: Philippe (born 1921), Élisabeth (1924–2013), who married General Alain de Boissieu, and Anne (1928–1948). Anne had Down syndrome and died of pneumonia at the age of 20. He always had a particular love for Anne; one Colombey resident recalled how he used to walk with her hand-in-hand around the property, caressing her and talking quietly about the things she understood.