After a deal with Sven-Göran Eriksson could not be agreed, the Fédération Camerounaise de Football appointed Seedorf as the manager of the Cameroon national team in August 2018. He was joined by former teammate Patrick Kluivert as his assistant manager. However, after a disappointing 2019 Africa Cup of Nations, where Cameroon was eliminated by Nigeria in the round of sixteen after an unimpressive group stage, he was sacked in July 2019.