He worked as an intern in Alsace Mechanical Industries until 1976, when he returned to Homeland. He worked at capital Metro as the operational director from 1976 to 1979.Mir-Salim served as the national police chief following the Revolution.He was proposed by then president Abulhassan Banisadr in July 1980 as a candidate for the prime minister as a compromise candidate acceptable to both Banisadr and the Majlis dominated by the Islamic Republican Party.
However, Banisadr was pressured to accept Mohammad-Ali Rajai instead.From 1981 to 1989, Mir-Salim was the advisor to then president Ayatollah Khamenei.In the beginning of 1989, on the occasion of the death and funeral of Hirohito, the 124th Emperor of Japan who had ruled for over 60 years until he died on January 7, Mir-Salim and Hossein Saffar Harandi, a Member of Parliament and the Chairman of Parliament Committee on Agriculture, went to the Imperial Palace in Tokyo to attend the Rites of Imperial Funeral on February 24 with Mohammad Hossein Adeli, Ambassador Extraordinary Plenipotentiary in Japan, and his wife.