He became the Prime Minister of Iran in March 1322.After the opening of the 14th session of the National Assembly, Saed, on the occasion of the major role he played in the position of the Ministry of Foreign Affairs for two consecutive years and considering the fact that he had worked in missions in the Soviet Union for many years and could better cope with that country, The desire of the representatives was met and on April 8, 1323, he introduced his cabinet to the parliament. During his eight months as prime minister, he reorganized his cabinet twice and held the position of foreign minister in all three cabinets. Mohammad Saed was twice prime minister, eight times minister of foreign affairs, once minister of interior, and four times ambassador and minister.