Paget’s disease of the nipple is an incredibly rare form of breast cancer where cancer cells collect in or around the nipple. According to the National Cancer Institute, Paget’s disease of the nipple accounts for less than 5 percent of all breast cancer cases in the United States. The first sign is scaly, red, itchy patches around the nipple and areola. “Sometimes it’s misdiagnosed as eczema of the nipple,” says Dr. Suozzi. “But when it’s breast cancer-associated it’s unilateral.” Itchy skin isn’t the only sign of disease; here are the 10 subtle signs of disease that your feet can show.